Joao Medeiros-Silva – Hong Lab MIT

Dr. João Medeiros-Silva

Utrecht University, Entry year: 2020
jmsilva@mit.edu

Publications

1

D. Santos, J. Medeiros-Silva, S. Cegonho, E. Alves, F. Ramilo-Gomes, A. O. Santos, S. Silvestre, C. Cruz, “Cell Proliferation Effects of Calix[4]Arene Derivatives“, Tetrahedron 71 (40), 7593–7599, (2015). doi: 10.1016/j.tet.2015.07.077.

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2

J. Medeiros-Silva, D. Mance, M. Daniëls, S. Jekhmane, K. Houben, M. Baldus, M. Weingarth, “1H-Detected Solid-State NMR Studies of Water-Inaccessible Proteins In Vitro and In Situ“, Angew. Chemie – Int. Ed. 55 (43), 13606–13610, (2016). doi: 10.1002/anie.201606594.

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3

J. Medeiros-Silva, A. Guédin, G. F. Salgado, J.-L. Mergny, J. A. Queiroz, E. J. Cabrita, C. Cruz, “Phenanthroline-Bis-Oxazole Ligands for Binding and Stabilization of G-Quadruplexes“, Biochim. Biophys. Acta – Gen. Subj. 1861 (5, Part B), 1281–1292, (2017). doi: 10.1016/j.bbagen.2016.11.024.

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4

J. Medeiros-Silva, S. Jekhmane, M. Baldus, M. Weingarth, “Hydrogen Bond Strength in Membrane Proteins Probed by Time-Resolved 1H-Detected Solid-State NMR and MD Simulations“, Solid State Nucl. Magn. Reson. 87, 80–85, (2017). doi: 10.1016/j.ssnmr.2017.03.003.

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5

K. M. Visscher, J. Medeiros-Silva, D. Mance, J. P. G. L. M. Rodrigues, M. Daniëls, A. M. J. J. Bonvin, M. Baldus, M. Weingarth, “Supramolecular Organization and Functional Implications of K + Channel Clusters in Membranes“,Angew. Chemie – Int. Ed. 56 (43), 13222–13227, (2017). doi: 10.1002/anie.201705723.

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6

P. Hariharan, E. Tikhonova, J. Medeiros-Silva, A. Jeucken, M. V Bogdanov, W. Dowhan, J. F. Brouwers, M. Weingarth, L. Guan, “Structural and Functional Characterization of Protein-Lipid Interactions of the Salmonella Typhimurium Melibiose Transporter MelB“, BMC Biol. (2018). doi: 10.1186/s12915-018-0553-0.

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7

A. A. Saracino, F. Fontana, S. Jekhmane, J. M. Silva, M. Weingarth, F. Gelain, “Elucidating Self-Assembling Peptide Aggregation via Morphoscanner: A New Tool for Protein-Peptide Structural Characterization“, Adv. Sci. 5 (8), 1800471, (2018). doi: 10.1002/advs.201800471.

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8

J. Medeiros-Silva, S. Jekhmane, A. L. Paioni, K. Gawarecka, M. Baldus, E. Swiezewska, E. Breukink, M. Weingarth, “High-Resolution NMR Studies of Antibiotics in Cellular Membranes“, Nat. Commun. 9 (1), 3963, (2018). doi: 10.1038/s41467-018-06314-x.

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9

S. Jekhmane^$, J. Medeiros-Silva^$, J. Li, F. Kümmerer, C. Müller-Hermes, M. Baldus, B. Roux, M. Weingarth, “Shifts in the Selectivity Filter Dynamics Cause Modal Gating in K+ Channels“, Nat. Commun. 10 (1), 123, (2019). doi: 10.1038/s41467-018-07973-6.

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10

J. Medeiros‐Silva, S. Jekhmane, E. Breukink, M. Weingarth, “Towards the Native Binding Modes of Antibiotics That Target Lipid II”, ChemBioChem 20 (14), 1731–1738, (2019). doi: 10.1002/cbic.201800796.

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11

S. Jekhmane, M. Prachar, R. Pugliese, F. Fontana, J. Medeiros‐Silva, F. Gelain, M. Weingarth, “Design Parameters of Tissue‐Engineering Scaffolds at the Atomic Scale“, Angew. Chemie Int. Ed. 58 (47), 16943–16951, (2019). doi: 10.1002/anie.201907880.

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12

O. Ribeiro, A. Viegas, V. M. R. Pires, J. Medeiros‐Silva, P. Bule, W. Chai, F. Marcelo, C. M. G. A. Fontes, E. J. Cabrita, A. S. Palma, A. L. Carvalho, “Molecular Basis for the Preferential Recognition of Β1,3‐1,4‐glucans by the Family 11 Carbohydrate‐binding Module from Clostridium Thermocellum“, FEBS J. febs.15162, (2019). doi: 10.1111/febs.15162.

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13

Medeiros-Silva, “Towards the Physiologically Relevant State with High-Resolution Solid State NMR“, Utrecht University, (2019). ISBN: 978-90-393-7219-7.

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14

R. Shukla^$, J. Medeiros-Silva^$, A. Parmar, B. J. A. Vermeulen, S. Das, A. L. Paioni, S. Jekhmane, J. Lorent, A. M. J. J. Bonvin, M. Baldus, M. Lelli, E. J. A. Veldhuizen, E. Breukink, I. Singh, M. Weingarth, “Mode of Action of Teixobactins in Cellular Membranes“, Nat. Commun. 11 (1), 1–10, (2020). doi: 10.1038/s41467-020-16600-2.

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15

W. Zhai, A. Lucini Paioni, X. Cai, S. Narasimhan, J. Medeiros-Silva, W. Zhang, A. Rockenbauer, M. Weingarth, Y. Song, M. Baldus, Y. Liu, “Postmodification via Thiol-Click Chemistry Yields Hydrophilic Trityl-Nitroxide Biradicals for Biomolecular High-Field Dynamic Nuclear Polarization“, J. Phys. Chem. B 124 (41), 9047–9060, (2020). doi: 10.1021/acs.jpcb.0c08321.

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16

Y.J.L. Lau, F. Fontana, L. Mandemaker, D. Wezendonk, B. Vermeer, A. M. J. J. Bonvin, R. de Vries, H. Zhang, K. Remaut, J. van den Dikkenburg, J. Medeiros-Silva, A. Hassan, B. Perrone, R. Kuemmerle, F. Gelain, W. Hennink, M. Weingarth^$, E. Enrico Mastrobattista^$, “Control over the fibrillization yield by varying the oligomeric nucleation propensities of self-assembling peptides “, Commun. Chem., in press.

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^$denotes equal contribution

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