Oberlin College
Entry year: 2015

vmandala@mit.edu

G. W. Stull, M. J. Moore, V. S. Mandala, N. A. Douglas, H. R. Kates, X. Qi, S. F. Brockington, P. S. Soltis, D. E. Soltis, and M. A. Gitzendanner, “A targeted enrichment strategy for massively parallel sequencing of angiosperm plastid genomes”, Appl. Plant Sci. 1 (2), apps.1200497 (2013).

V. S. Mandala, S. J. Loewus, and M. A. Mehta, “Monintoring Cocrystal Formation via In Situ Solid-State NMR“, J. Phys. Chem. Lett. 5, 3340-3344 (2014).

V. S. Mandala, S. Liao, B. Kwon and M. Hong, “Structural Basis of Inward Rectification in the Influenza M2 Proton Channel from Solid-State NMR”,  J. Mol. Biol. 429, 2192-2210 (2017).

V. S. Mandala, J. K. Williams, and M. Hong, “Structure and Dynamics of Membrane Proteins from Solid-State NMR”, Annu. Rev. Biophys. 47, 201-222 (2018).

V. S. Mandala, M. D. Gelenter, M. Hong, “Transport-Relevant Protein Conformational Dynamics and Water Dynamics on Multiple Time Scales in an Archetypal Proton Channel: Insights from Solid-State NMR”, J. Am. Chem. Soc.  140, 1514-1524 (2018).  doi: 10.1021/jacs.7b12464.

M.K. Roos^$, V.S. Mandala^$ and M. Hong, “Determination of Long-Range Distances by Fast Magic-Angle-Spinning Radiofrequency-Driven ¹⁹F-¹⁹F Dipolar Recoupling NMR”, J. Phys. Chem. B, 122 (40), 9302-9313 (2018). (^$ indicates equal contribution)  

V.S. Mandala and M. Hong, “High-sensitivity protein solid-state NMR spectroscopy”, Curr. Opin. Struc. Biol., 58, 183-190 (2019).

V.S. Mandala, S.Y. Liao, M.D. Gelenter and M. Hong, “Backbone Conformation of the Influenza Virus B M2 Protein in Lipid Bilayers from Solid-State NMR”, Sci. Rep., 9, 3725 (2019).

A.A. Shcherbakov, V.S. Mandala and M. Hong, “High-Sensitivity Detection of Nanometer ¹H-¹⁹F Distances for Protein Structure Determination by ¹H-Detected Fast MAS NMR”, J. Phys Chem. B, 123, 4387-4391 (2019).

B. Kwon^$, M. Roos^$, V.S. Mandala, A.A. Shcherbakov, and M. Hong, “Elucidating Relayed Proton Transfer Through a His-Trp-His Triad of a Transmembrane Proton Channel by Solid-State NMR”, J. Mol. Biol., in press (2019).

M.D. Gelenter, K.J. Smith^$, S.Y. Liao^$, V.S. Mandala, A.J. Dregni, M.S. Lamm, Y. Tian, W. Xu, D.J. Pochan, T.J. Tucker, Y. Su, and M. Hong, “The peptide hormone glucagon forms amyloid fibrils with two coexisting β-strand conformations”, Nat. Struct. Mol. Biol., 26, 592-598 (2019).

Featured in MIT News: Chemists discover structure of glucagon fibrils: Study may be a step toward shelf-stable versions of the hormone, which is used to control diabetes.

A.J. Dregni^$, V.S. Mandala^$, H. Wu^$, M.R. Elkins, H.K. Wang, I. Hung, W.F. DeGrado, and M. Hong, “In vitro 0N4R tau fibrils contain a monomorphic β-sheet core enclosed by dynamically heterogeneous fuzzy coat segments”, Proc. Natl. Acad. Sci. USA, 116 (33),  16357-16366 (2019).

Featured in MIT News: Characterizing tau aggregates in neurodegenerative diseases: New research reveals a structural model for amyloid fibrils that could aid in future medicinal interventions for Alzheimer’s, CTE, and more.

V.S. Mandala, A.R. Loftis, A.A. Shcherbakov, B.L. Pentelute,  and M. Hong, “Atomic structures of closed and open influenza B M2 proton channel reveal the conduction mechanism”, Nat. Struct. Mol. Biol., 27 (2), 160-167 (2020).

Featured in MIT News: Chemists unveil the structure of an influenza B protein: Findings could help researchers design drugs to treat influenza B infections.

V.S. Mandala, D. Loh, S.M. Shepard, M.B. Geeson, I.V. Sergeyev, D.G. Nocera, C. C. Cummins, and M. Hong, “Bacterial phosphate granules contain cyclic polyphosphates: Evidence from ³¹P solid-state NMR”, J. Am. Chem. Soc. 142, 18407-18421 (2020)

V.S. Mandala, M.J. McKay, A.A. Shcherbakov, A.J. Dregni, A. Kolocouris, and M. Hong, “Structure and drug binding of the SARS-CoV-2 envelope protein transmembrane domain in lipid bilayers”, Nat. Struct. Mol. Biol. in press (2020)

Featured in MIT News: Chemists discover the structure of a key coronavirus protein: The protein, which acts as an ion channel, could be a target for new drugs against the SARS-CoV-2 virus.

A.A. Shcherbakov, G. S. Hisao, V.S. Mandala, N. E. Thomas, M. Soltani, E. A. Salter, J. H. Davis Jr., K. Henzler-Wildman and M. Hong, “Drug-Binding Structure and Drug Dynamics of the Bacterial Transporter EmrE in Lipid Bilayers”, Nat. Comm., 12, 172 (2021).

M.D. Gelenter^$,V.S. Mandala^$, M.J.M. Niesen^$, D.A. Sharon^$, A. J. Dregni, A. P. Willard, and M. Hong, “Water orientation and dynamics in the closed and open influenza B virus M2 proton channels”, Commun. Biol., 4, 338 (2020).

^$ denotes equal contribution