Venkata S. Mandala

Oberlin College
Entry year: 2015




G. W. Stull, M. J. Moore, V. S. Mandala, N. A. Douglas, H. R. Kates, X. Qi, S. F. Brockington, P. S. Soltis, D. E. Soltis, and M. A. Gitzendanner, “A targeted enrichment strategy for massively parallel sequencing of angiosperm plastid genomes”, Appl. Plant Sci. 1 (2), apps.1200497 (2013).


V. S. Mandala, S. J. Loewus, and M. A. Mehta, “Monintoring Cocrystal Formation via In Situ Solid-State NMR“, J. Phys. Chem. Lett. 5, 3340-3344 (2014).


V. S. Mandala, S. Liao, B. Kwon and M. Hong, “Structural Basis of Inward Rectification in the Influenza M2 Proton Channel from Solid-State NMR”,  J. Mol. Biol. 429, 2192-2210 (2017).


V. S. Mandala, J. K. Williams, and M. Hong, “Structure and Dynamics of Membrane Proteins from Solid-State NMR”, Annu. Rev. Biophys. 47, 201-222 (2018).


V. S. Mandala, M. D. Gelenter, M. Hong, “Transport-Relevant Protein Conformational Dynamics and Water Dynamics on Multiple Time Scales in an Archetypal Proton Channel: Insights from Solid-State NMR”, J. Am. Chem. Soc.  140, 1514-1524 (2018).  doi: 10.1021/jacs.7b12464.


M.K. Roos$, V.S. Mandala$ and M. Hong, “Determination of Long-Range Distances by Fast Magic-Angle-Spinning Radiofrequency-Driven 19F-19F Dipolar Recoupling NMR”, J. Phys. Chem. B, 122 (40), 9302-9313 (2018). ($ indicates equal contribution)  


V.S. Mandala and M. Hong, “High-sensitivity protein solid-state NMR spectroscopy”, Curr. Opin. Struc. Biol., 58, 183-190 (2019).


V.S. Mandala, S.Y. Liao, M.D. Gelenter and M. Hong, “Backbone Conformation of the Influenza Virus B M2 Protein in Lipid Bilayers from Solid-State NMR”, Sci. Rep., 9, 3725 (2019).


A.A. Shcherbakov, V.S. Mandala and M. Hong, “High-Sensitivity Detection of Nanometer 1H-19F Distances for Protein Structure Determination by 1H-Detected Fast MAS NMR”, J. Phys Chem. B, 123, 4387-4391 (2019).


B. Kwon$, M. Roos$, V.S. Mandala, A.A. Shcherbakov, and M. Hong, “Elucidating Relayed Proton Transfer Through a His-Trp-His Triad of a Transmembrane Proton Channel by Solid-State NMR”, J. Mol. Biol., in press (2019).


M.D. Gelenter, K.J. Smith$, S.Y. Liao$, V.S. Mandala, A.J. Dregni, M.S. Lamm, Y. Tian, W. Xu, D.J. Pochan, T.J. Tucker, Y. Su, and M. Hong, “The peptide hormone glucagon forms amyloid fibrils with two coexisting β-strand conformations”, Nat. Struct. Mol. Biol., 26, 592-598 (2019).

Featured in MIT NewsChemists discover structure of glucagon fibrils: Study may be a step toward shelf-stable versions of the hormone, which is used to control diabetes.


V.S. Mandala, A.R. Loftis, A.A. Shcherbakov, B.L. Pentelute,  and M. Hong, “Atomic structures of closed and open influenza B M2 proton channel reveal the conduction mechanism”, Nat. Struct. Mol. Biol., 27 (2), 160-167 (2020).

Featured in MIT News: Chemists unveil the structure of an influenza B protein: Findings could help researchers design drugs to treat influenza B infections.


V.S. Mandala, D. Loh, S.M. Shepard, M.B. Geeson, I.V. Sergeyev, D.G. Nocera, C. C. Cummins, and M. Hong, “Bacterial phosphate granules contain cyclic polyphosphates: Evidence from 31P solid-state NMR”, J. Am. Chem. Soc. 142, 18407-18421 (2020)


A.A. Shcherbakov, G. S. Hisao, V.S. Mandala, N. E. Thomas, M. Soltani, E. A. Salter, J. H. Davis Jr., K. Henzler-Wildman and M. Hong, “Drug-Binding Structure and Drug Dynamics of the Bacterial Transporter EmrE in Lipid Bilayers”, Nat. Comm., 12, 172 (2021).


M.D. Gelenter$,V.S. Mandala$, M.J.M. Niesen$, D.A. Sharon$, A. J. Dregni, A. P. Willard, and M. Hong, “Water orientation and dynamics in the closed and open influenza B virus M2 proton channels”, Commun. Biol., 4, 338 (2020).

denotes equal contribution