Matthew R. Elkins

Swarthmore College
Entry year: 2014




M.R. Elkins, T. Wang, M. Nick, H. Jo, T. Lemmin, S. Prusiner, W.F. DeGrado, J. Stohr, M. Hong, “Structural Polymorphism of Alzheimer’s Beta-Amyloid Fibrils as Controlled by an E22 Switch: A Solid-State NMR Study“, J. Am. Chem. Soc. 138, 9840-9852 (2016).


M.R. Elkins, J. K. Williams, M. D. Gelenter, P. Dai, B.S. Kwon, I.V. Sergeyev, B.L. Pentelute, and M. Hong, “Cholesterol Binding Site of the Influenza M2 Protein in Lipid Bilayers from Solid-State NMR”, Proc. Natl. Acad. Sci. USA 114 (49), 12946-12951 (2017).

Featured in The Boston Globe:  MIT researchers gain new insight on how flu spreads from cell to cell in the body

Featured in MIT NewsCholesterol helps flu virus escape through host cell’s membrane: Study could shed light on how many other proteins bind with membrane cholesterol.


M.R. Elkins, I.V. Sergeyev, and M. Hong, “Determining Cholesterol Binding to Membrane Proteins by Cholesterol 13C Labeling in Yeast and Dynamic Nuclear Polarization NMR”, J. Am. Chem. Soc., 140, 45, 15437-15449 (2018).


M.R. Elkins and M. Hong, “Elucidating Ligand-Bound Structures of Membrane Proteins Using Solid-State NMR Spectroscopy”, Curr. Opin. Struct. Biol., 57, 103-109 (2019).


A.J. Dregni$, V.S. Mandala$, H. Wu$, M.R. Elkins, H.K. Wang, I. Hung, W.F. DeGrado, and M. Hong, “In vitro 0N4R tau fibrils contain a monomorphic β-sheet core enclosed by dynamically heterogeneous fuzzy coat segments”, Proc. Natl. Acad. Sci. USA, in press (2019).


B. Kwon, T. Mandal, M. R. Elkins, Y. Oh, Q. Cui and M. Hong, “Cholesterol Interactions with the Trimeric HIV Fusion Protein gp41 in Lipid Bilayers Investigated by Solid-State NMR Spectroscopy and Molecular Dynamics Simulations”, J. Mol. Biol., in press (2020).