hong-group-portraits-00097

Matthew R. Elkins

Swarthmore College
Entry year: 2014

melk@mit.edu

Publications

1

M.R. Elkins, T. Wang, M. Nick, H. Jo, T. Lemmin, S. Prusiner, W.F. DeGrado, J. Stohr, M. Hong, “Structural Polymorphism of Alzheimer’s Beta-Amyloid Fibrils as Controlled by an E22 Switch: A Solid-State NMR Study“, J. Am. Chem. Soc. 138, 9840-9852 (2016).

2

M.R. Elkins, J. K. Williams, M. D. Gelenter, P. Dai, B.S. Kwon, I.V. Sergeyev, B.L. Pentelute, and M. Hong, “Cholesterol Binding Site of the Influenza M2 Protein in Lipid Bilayers from Solid-State NMR”, Proc. Natl. Acad. Sci. USA 114 (49), 12946-12951 (2017).

Featured in The Boston Globe:  MIT researchers gain new insight on how flu spreads from cell to cell in the body

Featured in MIT NewsCholesterol helps flu virus escape through host cell’s membrane: Study could shed light on how many other proteins bind with membrane cholesterol.

3

M.R. Elkins, I.V. Sergeyev, and M. Hong, “Determining Cholesterol Binding to Membrane Proteins by Cholesterol 13C Labeling in Yeast and Dynamic Nuclear Polarization NMR”, J. Am. Chem. Soc., 140, 45, 15437-15449 (2018).

4

M.R. Elkins and M. Hong, “Elucidating Ligand-Bound Structures of Membrane Proteins Using Solid-State NMR Spectroscopy”, Curr. Opin. Struct. Biol., 57, 103-109 (2019).

5

A.J. Dregni$, V.S. Mandala$, H. Wu$, M.R. Elkins, H.K. Wang, I. Hung, W.F. DeGrado, and M. Hong, “In vitro 0N4R tau fibrils contain a monomorphic β-sheet core enclosed by dynamically heterogeneous fuzzy coat segments”, Proc. Natl. Acad. Sci. USA, in press (2019).

spectrometer-hong-lab-2