Alexander A. Shcherbakov

University of Washington
Entry year: 2016


Alex Shcherbakov on LinkedIn and Google Scholar


Aspiring research scientist seeking to integrate physical, biological, and computational techniques toward the development of therapeutics.



J.M. Anderson, B. L. Kier, A. A. Shcherbakov, and N.H. Andersen, “An Improved Capping Unit for Stabilizing the Ends of Associated β-Strand”, FEBS Letters, 588 (24), 4749–4753 (2014). doi: 10.1016/j.febslet.2014.11.006.


J.M. Anderson, B. L. Kier, B. Jurban, A. Byrne, I. Shu, L.A. Eidenschink, A.A. Shcherbakov, M. Hudson, R.M. Fesinmeyer, and N.H. Andersen, “Aryl-Aryl Interactions in Designed Peptide Folds: Spectroscopic Characteristics and Placement Issues for Optimal Structure Stabilization”, Biopolymers, 105 (6), 337 – 356 (2016). doi: 10.1002/bip.22821.


J.M. Anderson, B. Jurban, K.N.L. Huggins, A.A. Shcherbakov, I. Shu, B.L. Kier, and N.H. Andersen, “Nascent Hairpins in Proteins: Identifying Turn Loci and Quantitating Turn Contributions to Hairpin Stability“, Biochemistry, 55 (39), 5537 – 5553 (2016). doi: 10.1021/acs.biochem.6b00732.


J.M. Anderson, A.A. Shcherbakov, B.L. Kier, J. Kellock, I. Shu, A. Byrne, L.A. Eidenschink, and N.H. Andersen, “Optimization of a β-sheet-cap for long loop closure”, Biopolymers, 107 (3) (2017). doi: 10.1002/bip.22995.


J. K. Williams, A. A. Shcherbakov, J. Wang, M. Hong, “Protonation Equilibria and Pore-opening Structure of the Dual-histidine Influenza B Virus M2 Transmembrane Proton Channel from Solid-state NMR“, J. Biol. Chem. 292 (43), 17876-17884 (2017).


M. Roos, T. Wang, A. A. Shcherbakov, M. Hong. “Fast Magic-Angle-Spinning 19F Spin Exchange NMR for Determining Nanometer 19F-19F Distances in Proteins and Pharmaceutical Compounds“, J. Phys. Chem. B 122 (11), 2900-2911 (2018). doi: 10.1021/acs.jpcb.8b00310.


A. A. Shcherbakov, M. Hong. “Rapid Measurement of Long-Range Distances in Proteins by Multidimensional 13C-19F REDOR NMR Under Fast Magic-Angle Spinning“, J. Biomol. NMR 71, 31-43 (2018). doi: 10.1007/s10858-018-0187-0.


A.A. Shcherbakov, V.S. Mandala and M. Hong, “High-Sensitivity Detection of Nanometer 1H-19F Distances for Protein Structure Determination by 1H-Detected Fast MAS NMR”, J. Phys Chem. B, in press (2019).


B. Kwon$, M. Roos$, V.S. Mandala, A.A. Shcherbakov, and M. Hong, “Elucidating Relayed Proton Transfer Through a His-Trp-His Triad of a Transmembrane Proton Channel by Solid-State NMR”, J. Mol. Biol., 431, 2554-2566 (2019).


V.S. Mandala, A.R. Loftis, A.A. Shcherbakov, B.L. Pentelute,  and M. Hong, “Atomic structures of closed and open influenza B M2 proton channel reveal the conduction mechanism”, Nat. Struct. Mol. Biol., 27 (2), 160-167 (2020).


A.A. Shcherbakov, M. Roos, B. Kwon, and M. Hong, “Two-dimensional 19F-13C correlation NMR for 19F resonance assignment of fluorinated proteins”,  J. Biomol. NMR, 74, 193-204 (2020).


A.A. Shcherbakov, G. S. Hisao, V.S. Mandala, N. E. Thomas, M. Soltani, E. A. Salter, J. H. Davis Jr., K. Henzler-Wildman and M. Hong, “Drug-Binding Structure and Drug Dynamics of the Bacterial Transporter EmrE in Lipid Bilayers”, Nat. Comm., 12, 172 (2021).


A.A. Shcherbakov$, J. Medeiros-Silva$, N. Tran, M.D. Gelenter, and M. Hong, “From Angstroms to Nanometers: Measuring Interatomic Distances in Solid-State NMR”, Chemical Reviews (2021).

denotes equal contribution