University of Washington
Entry year: 2016

shchalex@mit.edu

Alex Shcherbakov on LinkedIn and Google Scholar

Aspiring research scientist seeking to integrate physical, biological, and computational techniques toward the development of therapeutics.

J.M. Anderson, B. L. Kier, A. A. Shcherbakov, and N.H. Andersen, “An Improved Capping Unit for Stabilizing the Ends of Associated β-Strand”, FEBS Letters, 588 (24), 4749–4753 (2014). doi: 10.1016/j.febslet.2014.11.006.

J.M. Anderson, B. L. Kier, B. Jurban, A. Byrne, I. Shu, L.A. Eidenschink, A.A. Shcherbakov, M. Hudson, R.M. Fesinmeyer, and N.H. Andersen, “Aryl-Aryl Interactions in Designed Peptide Folds: Spectroscopic Characteristics and Placement Issues for Optimal Structure Stabilization”, Biopolymers, 105 (6), 337 – 356 (2016). doi: 10.1002/bip.22821.

J.M. Anderson, B. Jurban, K.N.L. Huggins, A.A. Shcherbakov, I. Shu, B.L. Kier, and N.H. Andersen, “Nascent Hairpins in Proteins: Identifying Turn Loci and Quantitating Turn Contributions to Hairpin Stability“, Biochemistry, 55 (39), 5537 – 5553 (2016). doi: 10.1021/acs.biochem.6b00732.

J.M. Anderson, A.A. Shcherbakov, B.L. Kier, J. Kellock, I. Shu, A. Byrne, L.A. Eidenschink, and N.H. Andersen, “Optimization of a β-sheet-cap for long loop closure”, Biopolymers, 107 (3) (2017). doi: 10.1002/bip.22995.

J. K. Williams, A. A. Shcherbakov, J. Wang, M. Hong, “Protonation Equilibria and Pore-opening Structure of the Dual-histidine Influenza B Virus M2 Transmembrane Proton Channel from Solid-state NMR“, J. Biol. Chem. 292 (43), 17876-17884 (2017).

M. Roos, T. Wang, A. A. Shcherbakov, M. Hong. “Fast Magic-Angle-Spinning ¹⁹F Spin Exchange NMR for Determining Nanometer ¹⁹F-¹⁹F Distances in Proteins and Pharmaceutical Compounds“, J. Phys. Chem. B 122 (11), 2900-2911 (2018). doi: 10.1021/acs.jpcb.8b00310.

A. A. Shcherbakov, M. Hong. “Rapid Measurement of Long-Range Distances in Proteins by Multidimensional ¹³C-¹⁹F REDOR NMR Under Fast Magic-Angle Spinning“, J. Biomol. NMR 71, 31-43 (2018). doi: 10.1007/s10858-018-0187-0.

A.A. Shcherbakov, V.S. Mandala and M. Hong, “High-Sensitivity Detection of Nanometer ¹H-¹⁹F Distances for Protein Structure Determination by ¹H-Detected Fast MAS NMR”, J. Phys Chem. B, in press (2019).

B. Kwon^$, M. Roos^$, V.S. Mandala, A.A. Shcherbakov, and M. Hong, “Elucidating Relayed Proton Transfer Through a His-Trp-His Triad of a Transmembrane Proton Channel by Solid-State NMR”, J. Mol. Biol., 431, 2554-2566 (2019).

V.S. Mandala, A.R. Loftis, A.A. Shcherbakov, B.L. Pentelute,  and M. Hong, “Atomic structures of closed and open influenza B M2 proton channel reveal the conduction mechanism”, Nat. Struct. Mol. Biol., 27 (2), 160-167 (2020).

A.A. Shcherbakov, M. Roos, B. Kwon, and M. Hong, “Two-dimensional ¹⁹F-¹³C correlation NMR for ¹⁹F resonance assignment of fluorinated proteins”,  J. Biomol. NMR, 74, 193-204 (2020).

V.S. Mandala, M.J. McKay, A.A. Shcherbakov, A.J. Dregni, A. Kolocouris, and M. Hong, “Structure and drug binding of the SARS-CoV-2 envelope protein transmembrane domain in lipid bilayers”, Nat. Struct. Mol. Biol. in press (2020)

Featured in MIT News: Chemists discover the structure of a key coronavirus protein: The protein, which acts as an ion channel, could be a target for new drugs against the SARS-CoV-2 virus.

A.A. Shcherbakov, G. S. Hisao, V.S. Mandala, N. E. Thomas, M. Soltani, E. A. Salter, J. H. Davis Jr., K. Henzler-Wildman and M. Hong, “Drug-Binding Structure and Drug Dynamics of the Bacterial Transporter EmrE in Lipid Bilayers”, Nat. Comm., 12, 172 (2021).

A.A. Shcherbakov^$, J. Medeiros-Silva^$, N. Tran, M.D. Gelenter, and M. Hong, “From Angstroms to Nanometers: Measuring Interatomic Distances in Solid-State NMR”, Chemical Reviews (2021).

^$ denotes equal contribution