applying high-resolution
solid-state NMR spectroscopy
to elucidate the
structure & dynamics of
complex non-crystalline
biological macromolecules
Structural Biophysics From Solid-State NMR
The Hong group develops and applies magic-angle-spinning solid-state NMR spectroscopy to elucidate the structure and dynamics of biological macromolecules. We seek to understand how molecular conformation, motion, and intermolecular interactions enable proteins and carbohydrates to carry out their functions such as ion conduction across lipid membranes, membrane fusion between viruses and cells, membrane scission during virus budding, and maintenance and expansion of plant cell walls. We also investigate the structure and dynamics of amyloid proteins in neurodegenerative diseases. To answer these mechanistic biophysical questions, we innovate multinuclear (1H, 13C, 15N, 19F, 2H, & 31P) and multidimensional solid-state NMR techniques that measure molecular structure, inter-atomic distances, and amplitudes and rates of molecular motions with high sensitivity.
Lab News: Tweets by @MeiHongLab
- Check out C&EN's article on our SARS-CoV-2 E protein structure! https://t.co/KhIwwWUtZa 5 days ago
- Check out our new study of the SARS-CoV-2 envelope protein structure! https://t.co/bdoj8n1NwP. 2 weeks ago
- Thank you to the Nakanishi Prize Endowment for awarding me the Nakanishi Award (which will be presented at the 2021… https://t.co/plhWnthxFm 3 months ago
- We are excited to partner with CIL and use 13C-labelled glucose from them in our current study of a SARS-CoV-2 memb… https://t.co/vJMMWv7A0B 5 months ago
- Learn more about Pyae Phyo's scientific journey and her current research here at MIT! https://t.co/rlYbl5AcDj 8 months ago
- Congrats to Harrison Wang for giving a great talk on his tau project at the Biology Undergraduate Research symposi… https://t.co/R3FOx72cTT 10 months ago
Meet the Team
