applying high-resolution

solid-state NMR spectroscopy

to elucidate the

structure & dynamics of

complex non-crystalline

biological macromolecules

Structural Biophysics From Solid-State NMR

The Hong group develops and applies magic-angle-spinning solid-state NMR spectroscopy to elucidate the structure and dynamics of biological macromolecules. We seek to understand how molecular conformation, motion, and intermolecular interactions enable proteins and carbohydrates to carry out their functions such as ion conduction across lipid membranes, membrane fusion between viruses and cells, membrane scission during virus budding, and maintenance and expansion of plant cell walls. We also investigate the structure and dynamics of amyloid proteins in neurodegenerative diseases. To answer these mechanistic biophysical questions, we innovate multinuclear (1​​H, 1​3​C, 1​5N, 1​9​F, 2​​H, & 3​1​P) and multidimensional solid-state NMR techniques that measure molecular structure, inter-atomic distances, and amplitudes and rates of molecular motions with high sensitivity.


Lab News: Tweets by @MeiHongLab

  • Summer volleyball at MIT chemistry, here by the team of "magic angels"! 3 weeks ago
  • Solid-state NMR data reveal that the tau protein associates with microtubules through a pseudorepeat domain R', whi… 4 weeks ago
  • Jammy plants! See how impaired methylation of pectins lead to dwarf plants because of significant changes in the ce… 2 months ago
  • The small methyl group can do big things! Solid-state NMR reveals how de-methylation of pectins in plant cell walls… 2 months ago
  • Solid-state NMR data reveal that two versions of the protein tau are fluently mixed in the neurotoxic tangles in th… 3 months ago
  • 19F NMR illuminates how acidic pH and calcium ions change the sidechain conformation of two aromatic residues in th… 4 months ago

NMR Spectrometers

Meet the Team