applying high-resolution
solid-state NMR spectroscopy
to elucidate the
structure & dynamics of
complex non-crystalline
biological macromolecules
Structural Biophysics From Solid-State NMR
The Hong group develops and applies magic-angle-spinning solid-state NMR spectroscopy to elucidate the structure and dynamics of biological macromolecules. We seek to understand how molecular conformation, motion, and intermolecular interactions enable proteins and carbohydrates to carry out their functions such as ion conduction across lipid membranes, membrane fusion between viruses and cells, membrane scission during virus budding, and maintenance and expansion of plant cell walls. We also investigate the structure and dynamics of amyloid proteins in neurodegenerative diseases. To answer these mechanistic biophysical questions, we innovate multinuclear (1H, 13C, 15N, 19F, 2H, & 31P) and multidimensional solid-state NMR techniques that measure molecular structure, inter-atomic distances, and amplitudes and rates of molecular motions with high sensitivity.
Lab News: Tweets by @MeiHongLab
- 19F NMR illuminates how acidic pH and calcium ions change the sidechain conformation of two aromatic residues in th… https://t.co/0Cyj5nUkTn 1 month ago
- Second structure of EmrE determined by NMR, finally showing this transporter in action, using pH-controlled alterna… https://t.co/yoJxl3sMoP 3 months ago
- https://t.co/dPcJD8EhtE https://t.co/XeBKWIDmBJ 4 months ago
- 19F NMR lights up PET ligand binding sites in the Abeta peptide: neuroimaging of Alzheimers’ disease benefits from… https://t.co/TllIbZ27S3 4 months ago
- Check out our new Chemical Reviews article about seeing further by NMR – fluorines and protons create long distance… https://t.co/0fiwsWfUOk 7 months ago
- Wrapping the toxic core of the tau amyloid protein in a protective layer: C-terminus comes to the rescue! https://t.co/7F5SfAdWMF 1 year ago
Meet the Team
