applying high-resolution

solid-state NMR spectroscopy

to elucidate the

structure & dynamics of

complex non-crystalline

biological macromolecules

Structural Biophysics From Solid-State NMR

The Hong group develops and applies magic-angle-spinning solid-state NMR spectroscopy to elucidate the structure and dynamics of biological macromolecules. We seek to understand how molecular conformation, motion, and intermolecular interactions enable proteins and carbohydrates to carry out their functions such as ion conduction across lipid membranes, membrane fusion between viruses and cells, membrane scission during virus budding, and maintenance and expansion of plant cell walls. We also investigate the structure and dynamics of amyloid proteins in neurodegenerative diseases. To answer these mechanistic biophysical questions, we innovate multinuclear (1​​H, 1​3​C, 1​5N, 1​9​F, 2​​H, & 3​1​P) and multidimensional solid-state NMR techniques that measure molecular structure, inter-atomic distances, and amplitudes and rates of molecular motions with high sensitivity.


Lab News: Tweets by @MeiHongLab

  • Congratulations to Tuo Wang, one of our lab’s recent alumni, for receiving ISMAR’s Abragam Prize for his pioneering… 5 days ago
  • Proton hopping made easier: water molecules line up in the open influenza virus BM2 proton channel! 1 month ago
  • It takes two to tango: NMR and MD simulations reveal that cholesterol moves in pairs in biological membranes! 2 months ago
  • Confused about where to begin with Solid-State NMR or want to brush up on the basics? Take a look at our primer art… 3 months ago
  • Check out our EmrE structure solved using fast MAS 1H-19F solid-state NMR. 3 months ago
  • Check out C&EN's article on our SARS-CoV-2 E protein structure! 5 months ago

NMR Spectrometers

Meet the Team