applying high-resolution

solid-state NMR spectroscopy

to elucidate the

structure & dynamics of

complex non-crystalline

biological macromolecules

Structural Biophysics From Solid-State NMR

The Hong group develops and applies magic-angle-spinning solid-state NMR spectroscopy to elucidate the structure and dynamics of biological macromolecules. We seek to understand how molecular conformation, motion, and intermolecular interactions enable proteins and carbohydrates to carry out their functions such as ion conduction across lipid membranes, membrane fusion between viruses and cells, membrane scission during virus budding, and maintenance and expansion of plant cell walls. We also investigate the structure and dynamics of amyloid proteins in neurodegenerative diseases. To answer these mechanistic biophysical questions, we innovate multinuclear (1​​H, 1​3​C, 1​5N, 1​9​F, 2​​H, & 3​1​P) and multidimensional solid-state NMR techniques that measure molecular structure, inter-atomic distances, and amplitudes and rates of molecular motions with high sensitivity.


Lab News: Tweets by @MeiHongLab

  • A warm welcome to our newest postdoctoral associate, Dr. Nhi Tran! 3 weeks ago
  • Congrats to Marty, Shiva and Aurelio for receiving three poster awards at the Protein Society Meeting in Seattle! 1 month ago
  • Congratulations to Dr. Matthew R. Elkins for successfully defending his PhD thesis, "Protein-Ligand binding by Soli… 1 month ago
  • We kindly welcome our newest lab members to the team, postdocs Dr. Pu Duan and Dr. Matthew McKay along with graduat… 1 month ago
  • In a collaboration with the DeGrado lab at UCSF we identified a monomorphic fibril core surrounded by a dynamic fuz… 1 month ago
  • Check out our high-resolution structure of glucagon amyloid fibrils (PDB: 6NZN) featured in MIT News and published… 1 month ago

NMR Spectrometers

Meet the Team