applying high-resolution

solid-state NMR spectroscopy

to elucidate the

structure & dynamics of

complex non-crystalline

biological macromolecules

Structural Biophysics From Solid-State NMR

The Hong group develops and applies magic-angle-spinning solid-state NMR spectroscopy to elucidate the structure and dynamics of biological macromolecules. We seek to understand how molecular conformation, motion, and intermolecular interactions enable proteins and carbohydrates to carry out their functions such as ion conduction across lipid membranes, membrane fusion between viruses and cells, membrane scission during virus budding, and maintenance and expansion of plant cell walls. We also investigate the structure and dynamics of amyloid proteins in neurodegenerative diseases. To answer these mechanistic biophysical questions, we innovate multinuclear (1​​H, 1​3​C, 1​5N, 1​9​F, 2​​H, & 3​1​P) and multidimensional solid-state NMR techniques that measure molecular structure, inter-atomic distances, and amplitudes and rates of molecular motions with high sensitivity.


Lab News: Tweets by @MeiHongLab

  • Thank you to the Nakanishi Prize Endowment for awarding me the Nakanishi Award (which will be presented at the 2021… 2 months ago
  • We are excited to partner with CIL and use 13C-labelled glucose from them in our current study of a SARS-CoV-2 memb… 4 months ago
  • Learn more about Pyae Phyo's scientific journey and her current research here at MIT! 7 months ago
  • Congrats to Harrison Wang for giving a great talk on his tau project at the Biology Undergraduate Research symposi… 9 months ago
  • RT  @ChemistryMIT : A team of chemists, including Professor Mei Hong and  @PenteluteLab , have discovered the structure of a key influenza prot… 9 months ago
  • Check out our high-resolution structures of the influenza B M2 proton channel! The closed and open structures show… 9 months ago

NMR Spectrometers

Meet the Team